Manganese Enolates

The preparation of manganese enolates by deprotonation of ketones with manganese amides deserves also to be mentioned since the reaction is highly regio- and stereoselective and very simple to carry out.

Interestingly, further reactions of these reagents with various electrophiles take place without isomerization. It is currently the simplest way to perform the monoalkylation of a ketone without obtaining polyalkylation products.


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Selective Organic Synthesis and Organometallic Catalysis